Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0H6 6-({(2s)-3-cyclopentyl-2-[4-(trifluoromethyl)-1h-imidazol-1-yl]propanoyl}amino)pyridine-3-carboxylic acid
GLC Alpha-D-glucopyranose
NA Sodium ion
Code : 3VF6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE ACTIVATOR
Title : Glucokinase in complex with glucose and activator
Release Data : 2012-02-08
Compound :
mol_id molecule chains synonym
1 Glucokinase A Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
ec: 2.7.1.2
fragment: UNP residues 12-465
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GCK
Authors : Liu, S.
Keywords : catalysis reaction, TRANSFERASE, TRANSFERASE-TRANSFERASE ACTIVATOR complex
Exp. method : X-RAY DIFFRACTION ( 1.86 Å )
Citation :

Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.

Liu, S.,Ammirati, M.J.,Song, X.  et al.
(2012)  J.Biol.Chem.  287 : 13598 - 13610

PubMed: 22298776
DOI: 10.1074/jbc.M111.274126

Chain : A
UniProt : P35557 (HXK4_HUMAN)
Reaction : ATP + D-glucose = ADP + D-glucose 6-phosphate.