Brand  (β version)

PDB ID: 3VCY

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Ligands
Code Name Style Show Link
FFQ [(1r)-1-hydroxypropyl]phosphonic acid PoSSuM
UD1 Uridine-diphosphate-N-acetylglucosamine PoSSuM
PO4 Phosphate ion PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 3VCY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/ANTIBIOTIC
Title : Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase), from Vibrio fischeri in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin.
Release Data : 2012-04-11
Compound :
mol_id molecule chains synonym
1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase A,B,C,D Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT
ec: 2.5.1.7
Source :
mol_id organism_scientific expression_system
1 Vibrio fischeri  (taxid:388396) Escherichia coli  (taxid:469008)
strain: MJ11
gene: murA, VFMJ11_0391
expression_system_strain: BL21 Star (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28a
Authors : Bensen, D.C., Rodriguez, S., Nix, J., Cunningham, M.L., Tari, L.W.
Keywords : MurA, fosfomycin, peptidoglycan, Amino sugar and nucleotide sugar metabolism, Peptidoglycan biosynthesis, Cytosol, TRANSFERASE-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 1.925 Å )
Citation :

Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) from Vibrio fischeri in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin.

Bensen, D.C.,Rodriguez, S.,Nix, J.  et al.
(2012)  Acta Crystallogr.,Sect.F  68 : 382 - 385

PubMed: 22505403
DOI: 10.1107/S1744309112006720

Reaction

Chain : A, B, C, D
UniProt : B5F9P4 (MURA_ALIFM)
Reaction: EC: Evidence:
Physiological Direction:
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + phosphate 2.5.1.7 HAMAP-Rule:MF_00111
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