Brand  (β version)

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hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
03M (5z)-5-[(6-chloro-7-methyl-1h-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione
Code : 3VBG
Header : Ligase/ligase activator
Title : Structure of hDM2 with Dimer Inducing Indolyl Hydantoin RO-2443
Release Data : 2012-06-27
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase Mdm2 A,B,C,D Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
ec: 6.3.2.-
fragment: unp residues 25-109
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
strain: Human
gene: MDM2
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: PQE40
Authors : Lukacs, C.M., Janson, C.A., Graves, B.J.
Keywords : Ligase, MDM2, MDMX, P53, Ligase-ligase activator complex
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.

Graves, B.,Thompson, T.,Xia, M.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 11788 - 11793

PubMed: 22745160
DOI: 10.1073/pnas.1203789109

Chain : A, B, C, D
UniProt : Q00987 (MDM2_HUMAN)
Reaction : S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin- conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.