Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0FY 3-(1-{2-[(3-fluoropyridinium-4-yl)amino]-2-oxoethyl}-1h-pyrazol-4-yl)-6-methyl-8-[(3-{[(1r,3r)-3-methylpiperidinium-1-yl]methyl}-1,2-thiazol-5-yl)amino]imidazo[1,2-a]pyrazin-1-ium
Code : 3VAP
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
Release Data : 2012-05-02
Compound :
mol_id molecule chains synonym
1 Aurora kinase A A Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A
ec: 2.7.11.1
fragment: UNP Residues 125-391
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: PDEST14
Authors : Voss, M.E., Rainka, M.P., Fleming, M., Peterson, L.H., Belanger, D.B., Siddiqui, M.A., Hruza, A., Voigt, J., Basso, A.D., Gray, K.
Keywords : kinase, cell cycle, inhibitor, transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.66 Å )
Citation :

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.

Voss, M.E.,Rainka, M.P.,Fleming, M.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 3544 - 3549

PubMed: 22503250
DOI: 10.1016/j.bmcl.2012.03.051

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.