Het-PDB Navi2 (PDB: 3VAP)

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Ligands
Code	Name		Style	Show	Link
0FY	3-(1-{2-[(3-fluoropyridinium-4-yl)amino]-2-oxoethyl}-1h-pyrazol-4-yl)-6-methyl-8-[(3-{[(1r,3r)-3-methylpiperidinium-1-yl]methyl}-1,2-thiazol-5-yl)amino]imidazo[1,2-a]pyrazin-1-ium				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3VAP

Code :

3VAP PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity

Release Data :

2012-05-02

Compound :

mol_id	molecule	chains	synonym
1	Aurora kinase A	A	Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A
	ec: 2.7.11.1 fragment: UNP Residues 125-391

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:511693)
	gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6 expression_system_strain: BL21 expression_system_vector_type: PLASMID expression_system_plasmid: PDEST14

Authors :

Voss, M.E., Rainka, M.P., Fleming, M., Peterson, L.H., Belanger, D.B., Siddiqui, M.A., Hruza, A., Voigt, J., Basso, A.D., Gray, K.

Keywords :

kinase, cell cycle, inhibitor, transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.66 Å )

Citation :

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.

Voss, M.E.,Rainka, M.P.,Fleming, M. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 3544 - 3549

Chain :

UniProt :

O14965 (AURKA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27192185, PubMed:27837025, PubMed:28218735
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
	-

PDB ID: 3VAP