Het-PDB Navi2 (PDB: 3VAF)

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Ligands
Code	Name	Link
CPQ	N,N-bis(3-D-gluconamidopropyl)deoxycholamide	PoSSuM
DIO	1,4-diethylene dioxide	PoSSuM
GOL	Glycerol	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
Code	Name	Show
BRU	5-bromo-2'-deoxyuridine-5'-monophosphate

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3VAF

Code :

3VAF PDBj RCSB PDB PDBe

Header :

RNA BINDING PROTEIN/DNA

Title :

Structure of U2AF65 variant with BrU3 DNA

Release Data :

2013-02-13

Compound :

mol_id	molecule	chains	synonym
1	Splicing factor U2AF 65 kDa subunit	A,B	U2 auxiliary factor 65 kDa subunit, hU2AF(65), hU2AF65, U2 snRNP auxiliary factor large subunit
	fragment: RNA Binding Domains 1 and 2

mol_id	molecule	chains
2	DNA 5'-D(UPUP(BRU)P(BRU)PUPUP*U)-3'	P,E
	other_details: BrU3 DNA

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: U2AF2, U2AF65 expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: PGEX-6P

mol_id	organism_scientific
2
	synthetic: yes other_details: DNA

Authors :

Jenkins, J.L., Kielkopf, C.L.

Keywords :

RNA SPLICING FACTOR, RNA RECOGNITION MOTIF, RNA BINDING PROTEIN-DNA complex

Exp. method :

X-RAY DIFFRACTION ( 2.4900 Å )

Citation :

U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.

Jenkins, J.L.,Agrawal, A.A.,Gupta, A. et al.
(2013) Nucleic Acids Res. 41 : 3859 - 3873

PDB ID: 3VAF