Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0F0 3-{[4-(dimethylamino)butanoyl]amino}-N-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
Code : 3V6S
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Discovery of potent and selective covalent inhibitors of JNK
Release Data : 2012-02-01
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 10 A,B MAP kinase 10, MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK10, JNK3, JNK3A, PRKM10, SAPK1B
Authors : Park, H., Laughlin, J.D., LoGrasso, P.V.
Keywords : KINASE FOLD, APOPTOSIS, MAP KINASE, CYS modification, JNK, Phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.97 Å )
Citation :

Discovery of potent and selective covalent inhibitors of JNK.

Zhang, T.,Inesta-Vaquera, F.,Niepel, M.  et al.
(2012)  Chem.Biol.  19 : 140 - 154

PubMed: 22284361
DOI: 10.1016/j.chembiol.2011.11.010

Chain : A, B
UniProt : P53779 (MK10_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.