Het-PDB Navi2 (PDB: 3V6S)

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Ligands
Code	Name		Style	Show	Link
0F0	3-{[4-(dimethylamino)butanoyl]amino}-N-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3V6S

Code :

3V6S PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Discovery of potent and selective covalent inhibitors of JNK

Release Data :

2012-02-01

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 10	A,B	MAP kinase 10, MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3
	ec: 2.7.11.24

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MAPK10, JNK3, JNK3A, PRKM10, SAPK1B

Authors :

Park, H., Laughlin, J.D., LoGrasso, P.V.

Keywords :

KINASE FOLD, APOPTOSIS, MAP KINASE, CYS modification, JNK, Phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.97 Å )

Citation :

Discovery of potent and selective covalent inhibitors of JNK.

Zhang, T.,Inesta-Vaquera, F.,Niepel, M. et al.
(2012) Chem.Biol. 19 : 140 - 154

Chain :

A, B

UniProt :

P53779 (MK10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	-
	-	-

PDB ID: 3V6S