Brand  (β version)

PDB ID: 3V5Q

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
0F4 1-(3-{[(3z)-2-oxo-3-(1h-pyrrol-2-ylmethylidene)-2,3-dihydro-1h-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3V5Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models
Release Data : 2012-02-08
Compound :
mol_id molecule chains synonym
1 NT-3 growth factor receptor A,B GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase
ec: 2.7.10.1
fragment: Kinase Domain (UNP Residues 530-818)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: NTRK3, TRKC
expression_system_strain: SF9
expression_system_vector_type: Plasmid
expression_system_plasmid: pFastBac
Authors : Kreusch, A.
Keywords : Kinase Domain, Kinase, Phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.2001 Å )
Citation :

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.

Albaugh, P.,Fan, Y.,Mi, Y.  et al.
(2012)  ACS Med Chem Lett  3 : 140 - 145

PubMed: 24900443
DOI: 10.1021/ml200261d

Reaction

Chain : A, B
UniProt : Q16288 (NTRK3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028
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