Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
MG Magnesium ion
0FV (2z)-2-fluoro-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
Code : 3V1X
Header : LYASE
Title : Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and 2-fluorogeranyl diphosphate
Release Data : 2012-04-11
Compound :
mol_id molecule chains synonym
1 2-methylisoborneol synthase A 2-MIB synthase
ec: 4.2.3.-
Source :
mol_id organism_scientific expression_system
1 Streptomyces coelicolor  (taxid:100226) Escherichia coli  (taxid:469008)
strain: A3(2)
gene: SC1A4.08, SCBAC12C8.01, SCO7700
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28a
Authors : Koksal, M., Christianson, D.W.
Keywords : class I terpenoid cyclase fold, DDXXXXD motif, NDXXSXXXE motif, 2-methylisoborneol biosynthesis, Biosynthesis of 2-methylisoborneol, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.955 Å )
Citation :

Structure of 2-Methylisoborneol Synthase from Streptomyces coelicolor and Implications for the Cyclization of a Noncanonical C-Methylated Monoterpenoid Substrate.

Koksal, M.,Chou, W.K.,Cane, D.E.  et al.
(2012)  Biochemistry  51 : 3011 - 3020

PubMed: 22455514
DOI: 10.1021/bi201827a

Chain : A
UniProt : Q9F1Y6 (MIBS_STRCO)
Reaction : (E)-2-methylgeranyl diphosphate + H(2)O = 2- methylisoborneol + diphosphate.