Brand  (β version)

PDB ID: 3V1R

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Ligands
Code Name Style Show Link
JTH 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one PoSSuM
MN Manganese (II) ion PoSSuM
MRD (4r)-2-methylpentane-2,4-diol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3V1R   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structures of the reverse transcriptase-associated ribonuclease H domain of XMRV with inhibitor beta-thujaplicinol
Release Data : 2012-03-14
Compound :
mol_id molecule chains
1 Reverse transcriptase/ribonuclease H p80 A
ec: 3.1.26.4
fragment: RNase H domain (UNP residues 1154-1328)
Source :
mol_id organism_scientific organism_common expression_system
1 Xenotropic MuLV-related virus VP35  (taxid:356663) XMRV Escherichia coli  (taxid:562)
gene: gag-pol, POL_XMRV3
Authors : Zhou, D., Wlodawer, A.
Keywords : Reverse Transcription, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.800 Å )
Citation :

Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus.

Zhou, D.,Chung, S.,Miller, M.  et al.
(2012)  J.Struct.Biol.  177 : 638 - 645

PubMed: 22366278
DOI: 10.1016/j.jsb.2012.02.006

Reaction

Chain : A
UniProt : Q2F7J3 (POL_XMRV3)
Reaction: EC: Evidence:
Physiological Direction:
[Reverse transcriptase/ribonuclease H p80]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.49 PROSITE- ProRule:PRU00405
-
[Reverse transcriptase/ribonuclease H p80]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.7 PROSITE- ProRule:PRU00405
-
[Protease p14]
Endonucleolytic cleavage to 5'-phosphomonoester. 		3.1.26.4 PROSITE-ProRule:PRU00408
-