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PDB ID: 3UZP

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Ligands
Code Name Style Show Link
0CK 4-[1-cyclohexyl-4-(4-fluorophenyl)-1h-imidazol-5-yl]pyrimidin-2-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3UZP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : crystal structure of ck1d with PF670462 from P21 crystal form
Release Data : 2012-01-11
Compound :
mol_id molecule chains synonym
1 Casein kinase I isoform delta A,B CKI-delta, CKId
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CSNK1D
Authors : Huang, X.
Keywords : ck1d, kinase, inhibitor, PF670462, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.94 Å )
Citation :

Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.

Long, A.,Zhao, H.,Huang, X.
(2012)  J.Med.Chem.  55 : 956 - 960

PubMed: 22168824
DOI: 10.1021/jm201387s

Reaction

Chain : A, B
UniProt : P48730 (KC1D_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12270943, PubMed:14761950, PubMed:16618118, PubMed:17562708, PubMed:17962809, PubMed:19043076, PubMed:19591487, PubMed:20041275, PubMed:20048001, PubMed:20637175, PubMed:20699359, PubMed:21084295, PubMed:21422228, PubMed:23636092
left-to-right PubMed:20637175
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:10606744, PubMed:14761950, PubMed:17562708, PubMed:19591487, PubMed:20041275, PubMed:20637175, PubMed:21422228, PubMed:23636092
left-to-right PubMed:20637175
ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein] 2.7.11.26 PubMed:14761950, PubMed:16618118, PubMed:17562708
left-to-right PubMed:14761950
ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein] 2.7.11.26 PubMed:14761950, PubMed:16618118, PubMed:17562708
left-to-right PubMed:14761950