Brand  (β version)

PDB ID: 3UZB

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Ligands
Code Name Style Show Link
PLP Pyridoxal-5'-phosphate PoSSuM
COI 2-oxo-4-methylpentanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3UZB   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structures of Branched-Chain Aminotransferase from Deinococcus radiodurans Complexes with alpha-Ketoisocaproate and L-Glutamate Suggest Its Radio-Resistance for Catalysis
Release Data : 2012-12-12
Compound :
mol_id molecule chains
1 Branched-chain-amino-acid aminotransferase A,B,C,D
ec: 2.6.1.42
Source :
mol_id organism_scientific expression_system
1 Deinococcus radiodurans  (taxid:1299) Escherichia coli  (taxid:562)
strain: R1
gene: DR_1626
expression_system_vector_type: PLASMID
expression_system_plasmid: pQE30
Authors : Chen, C.D., Huang, Y.C., Chuankhayan, P., Hsieh, Y.C., Huang, T.F., Lin, C.H., Guan, H.H., Liu, M.Y., Chang, W.C., Chen, C.J.
Keywords : BCAT, Amino-acid biosynthesis, Aminotransferase, Branched-chain amino acid biosynthesis, Pyridoxal phosphate, Transferase, alpha-Ketoisocaproate
Exp. method : X-RAY DIFFRACTION ( 3.0 Å )
Citation :

Crystal Structures of Complexes of the Branched-Chain Aminotransferase from Deinococcus radiodurans with alpha-Ketoisocaproate and L-Glutamate Suggest the Radiation Resistance of This Enzyme for Catalysis

Chen, C.D.,Lin, C.H.,Chuankhayan, P.  et al.
(2012)  J.Bacteriol.  194 : 6206 - 6216

PubMed: 22984263
DOI: 10.1128/JB.01659-12

Reaction

Chain : A, B, C, D
UniProt : Q9RTX5 (Q9RTX5_DEIRA)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate 2.6.1.42 ARBA:ARBA00000627, RuleBase:RU004517
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2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L- glutamate 2.6.1.42 ARBA:ARBA00000995, RuleBase:RU004517
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2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L- glutamate 2.6.1.42 ARBA:ARBA00001745, RuleBase:RU004517
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