Brand  (β version)

PDB ID: 3UVV

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Ligands
Code Name Style Show Link
9CR (9cis)-retinoic acid PoSSuM
T3 3,5,3'triiodothyronine PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 3UVV   PDBj   RCSB PDB   PDBe
Header : HORMONE RECEPTOR/HORMONE RECEPTOR
Title : Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid
Release Data : 2012-04-18
Compound :
mol_id molecule chains synonym
1 Thyroid hormone receptor alpha A Nuclear receptor subfamily 1 group A member 1
fragment: ligand binding domain (UNP Residues 147-407)
mol_id molecule chains synonym
2 Retinoic acid receptor RXR-alpha B Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha
fragment: ligand binding domain (UNP Residues 225-462)
Source :
mol_id organism_scientific organism_common expression_system
1 Gallus gallus  (taxid:9031) Bantam,chickens Escherichia coli  (taxid:469008)
gene: THRA, NR1A1
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET 15b
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: RXRA, NR2B1
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pACYC184
Authors : Fernandez, E.J., Putcha, B.-D.K., Wright, E., Brunzelle, J.S.
Keywords : TR-RXR heterodimer, allostery, alpha helical sandwich, transactivation, HORMONE RECEPTOR-HORMONE RECEPTOR complex
Exp. method : X-RAY DIFFRACTION ( 2.95 Å )
Citation :

Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers.

Putcha, B.D.,Wright, E.,Brunzelle, J.S.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 6084 - 6087

PubMed: 22474364
DOI: 10.1073/pnas.1119852109

Reaction

Chain : A
UniProt : P04625 (THA_CHICK)
Reaction : -
Chain : B
UniProt : P19793 (RXRA_HUMAN)
Reaction : -