Brand  (β version)

PDB ID: 3UVP

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Ligands
Code Name Style Show Link
048 N-{2-fluoro-5-[(5-oxo-6,7,8,9-tetrahydro-5h-benzo[7]annulen-2-yl)amino]phenyl}benzamide PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Structure summary

Code : 3UVP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone
Release Data : 2012-11-07
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, SAPK2A
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pGEX 6P-1
Authors : Mayer-Wrangowski, S.C., Richters, A., Gruetter, C., Rauh, D.
Keywords : protein kinase, selective p38 inhibitor, SAR, benzosuberon derivative, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38 alpha Inhibitors.

Martz, K.E.,Dorn, A.,Baur, B.  et al.
(2012)  J.Med.Chem.  55 : 7862 - 7874

PubMed: 22897496
DOI: 10.1021/jm300951u

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590