Brand  (β version)

PDB ID: 3UVC

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CA Calcium ion PoSSuM
IMD Imidazole PoSSuM
CL Chloride ion PoSSuM
0D2 (4r,4'S)-4,4'-diphenyl-4,4'-biimidazolidine-2,2',5,5'-tetrone PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 3UVC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : MMP12 in a complex with the dimeric adduct: 5-(5-phenylhydantoin)-5-phenylhydantoin
Release Data : 2013-01-02
Compound :
mol_id molecule chains synonym
1 Macrophage metalloelastase A,B MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12
ec: 3.4.24.65
fragment: CATALYTIC DOMAIN, RESIDUES 106-263
mutation: E216A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: 4321, HME, MMP12
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: Pet11a
Authors : Derbyshire, D.J., Danielson, H., Nystrum, S.
Keywords : hydrolase, metalloprotease
Exp. method : X-RAY DIFFRACTION ( 1.3000 Å )
Citation :

Characterization of fragments interacting with MMP-12

Nordstrom, H.,Gossas, T.,Derbyshire, D.J.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : P39900 (MMP12_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin. 3.4.24.65 -
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Cofactor: Evidence: Note:
Ca(2+) - Binds 4 Ca(2+) ions per subunit.
Zn(2+) - Binds 2 Zn(2+) ions per subunit.