Brand  (β version)

PDB ID: 3UT6

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Ligands
Code Name Style Show Link
FMC (1s)-1-(7-amino-1h-pyrazolo[4,3-D]pyrimidin-3-yl)-1,4-anhydro-D-ribitol PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3UT6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of E. Coli PNP complexed with PO4 and formycin A
Release Data : 2012-05-23
Compound :
mol_id molecule chains synonym
1 Purine nucleoside phosphorylase deoD-type A,B,C PNP, Inosine phosphorylase
ec: 2.4.2.1
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:83333)
strain: K12
Authors : Stefanic, Z.
Keywords : purine nucleoside phosphorylase, formycin, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.8950 Å )
Citation :

New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A.

Stefanic, Z.,Narczyk, M.,Mikleusevic, G.  et al.
(2012)  Febs Lett.  586 : 967 - 971

PubMed: 22569248
DOI: 10.1016/j.febslet.2012.02.039

Reaction

Chain : A, B, C
UniProt : P0ABP8 (DEOD_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate 2.4.2.1 HAMAP-Rule:MF_01627
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a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy- alpha-D-ribose 1-phosphate + a purine nucleobase 2.4.2.1 HAMAP-Rule:MF_01627
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inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine 2.4.2.1 PubMed:21672603, PubMed:235429, PubMed:11786017
right-to-left PubMed:235429
adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate 2.4.2.1 PubMed:21672603, PubMed:235429, PubMed:30337572
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guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine 2.4.2.1 PubMed:21672603, PubMed:235429
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2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + adenine 2.4.2.1 PubMed:235429
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2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine 2.4.2.1 PubMed:235429
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2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine 2.4.2.1 PubMed:235429
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