Brand  (β version)

PDB ID: 3UT5

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Ligands
Code Name Style Show Link
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
LOC N-[(7s)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5h-benzo[D]heptalen-7-yl]ethanamide PoSSuM
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
0E5 (2s,3r)-2-azanyl-3-methyl-3-oxidanyl-pentanoic acid
0EA (betar)-beta,3-dihydroxy-N-methyl-L-tyrosine
Glycosylation
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Modification
Code Name Show

Structure summary

Code : 3UT5   PDBj   RCSB PDB   PDBe
Header : STRUCTURAL PROTEIN/INHIBITOR
Title : Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex
Release Data : 2012-08-01
Compound :
mol_id molecule chains
1 Tubulin alpha chain A,C
mol_id molecule chains
2 Tubulin beta chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3, RB3
mutation: C58A, F64W
mol_id molecule chains
4 Vinca tetrapeptide F
Source :
mol_id organism_scientific organism_common
1 Ovis aries  (taxid:9940) Domestic sheep,lambs,wild sheep
mol_id organism_scientific organism_common
2 Ovis aries  (taxid:9940) Domestic sheep,lambs,wild sheep
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:469008)
gene: Stmn4
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-8C
mol_id organism_scientific
4
synthetic: yes
Authors : Ranaivoson, F.M., Gigant, B., Knossow, M.
Keywords : Microtubules, Tubulin, Vinca domain, Ustiloxin, Stathmin, STRUCTURAL PROTEIN, STRUCTURAL PROTEIN-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.73 Å )
Citation :

Structural plasticity of tubulin assembly probed by vinca-domain ligands.

Ranaivoson, F.M.,Gigant, B.,Berritt, S.  et al.
(2012)  Acta Crystallogr.,Sect.D  68 : 927 - 934

PubMed: 22868758
DOI: 10.1107/S0907444912017143

Reaction

Chain : A, C
UniProt : D0VWZ0 (D0VWZ0_SHEEP)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - ARBA:ARBA00001702
left-to-right
Chain : B, D
UniProt : D0VWY9 (D0VWY9_SHEEP)
Reaction : -
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -