Brand  (β version)

PDB ID: 3UR4

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Ligands
Code Name Style Show Link
0BW Methyl 3-[(3-methoxybenzoyl)amino]-4-(4-methylpiperazin-1-yl)benzoate PoSSuM
EDO 1,2-ethanediol PoSSuM
CL Chloride ion PoSSuM
SO4 Sulfate ion PoSSuM
UNX Unknown atom or ion PoSSuM
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Structure summary

Code : 3UR4   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/INHIBITOR
Title : Crystal structure of human WD repeat domain 5 with compound
Release Data : 2011-12-14
Compound :
mol_id molecule chains synonym
1 WD repeat-containing protein 5 A,B BMP2-induced 3-kb gene protein
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: WDR5, BIG3
expression_system_strain: BL21(DE3) V2RpRARE
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28-MHL
Authors : Dong, A., Dombrovski, L., Senisterra, G., Wernimont, A., Wasney, G.A., Allali Hassani, A., Nguyen, K.T., Smil, D., Bolshan, Y., Hajian, T., Poda, G., Chau, I., Al-Awar, R., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Brown, P., Schapira, M., Vedadi, M., Wu, H., Structural Genomics Consortium (SGC)
Keywords : Structural Genomics, Structural Genomics Consortium, SGC, TRANSCRIPTION, WD REPEAT DOMAIN 5, WDR5, TRANSCRIPTION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.

Senisterra, G.,Wu, H.,Allali-Hassani, A.  et al.
(2013)  Biochem. J.  449 : 151 - 159

PubMed: 22989411
DOI: 10.1042/BJ20121280

Reaction

Chain : A, B
UniProt : P61964 (WDR5_HUMAN)
Reaction : -