Brand  (β version)

PDB ID: 3UOL

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Ligands
Code Name Style Show Link
0C7 N~4~-(2-chlorophenyl)-N~2~-[4-(1h-tetrazol-5-yl)phenyl]pyrimidine-2,4-diamine PoSSuM
EDO 1,2-ethanediol PoSSuM
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Structure summary

Code : 3UOL   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Aurora A in complex with SO2-162
Release Data : 2012-01-25
Compound :
mol_id molecule chains synonym
1 Aurora kinase A A,B Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A
ec: 2.7.11.1
fragment: Kinase domain, RESIDUES 123-401
mutation: T287D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
expression_system_strain: TUNER(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28a-MBP
Authors : Martin, M.P., Zhu, J.-Y., Schonbrunn, E.
Keywords : protein kinase, Aurora A, inhibitor, DFG-out, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.400 Å )
Citation :

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A.

Martin, M.P.,Zhu, J.Y.,Lawrence, H.R.  et al.
(2012)  Acs Chem.Biol.  7 : 698 - 706

PubMed: 22248356
DOI: 10.1021/cb200508b

Reaction

Chain : A, B
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27192185, PubMed:27837025, PubMed:28218735
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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