Brand  (β version)

PDB ID: 3UO9

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Ligands
Code Name Style Show Link
04A N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide) PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 3UO9   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of Human GAC in Complex with Glutamate and BPTES
Release Data : 2011-12-07
Compound :
mol_id molecule chains synonym
1 Glutaminase kidney isoform, mitochondrial A,B,C,D GLS, K-glutaminase, L-glutamine amidohydrolase
ec: 3.5.1.2
fragment: unp residues 71-598
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GLS, GLS1, KIAA0838
Authors : DeLaBarre, B., Gross, S., Cheng, F., Gao, Y., Jha, A., Jiang, F., Song, J.J., Wei, W., Hurov, J.B.
Keywords : HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Full-length human glutaminase in complex with an allosteric inhibitor.

DeLaBarre, B.,Gross, S.,Fang, C.  et al.
(2011)  Biochemistry  50 : 10764 - 10770

PubMed: 22049910
DOI: 10.1021/bi201613d

Reaction

Chain : A, B, C, D
UniProt : O94925 (GLSK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + L-glutamine = L-glutamate + NH4(+) 3.5.1.2 PubMed:22049910, PubMed:22538822, PubMed:24451979, PubMed:26988803, PubMed:28526749, PubMed:29317493
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