Het-PDB Navi2 (PDB: 3UO5)

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Ligands
Code	Name		Style	Show	Link
0BX	4-{[4-(phenylamino)pyrimidin-2-yl]amino}benzoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3UO5

Code :

3UO5 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Aurora A in complex with YL1-038-31

Release Data :

2012-01-25

Compound :

mol_id	molecule	chains	synonym
1	Serine/Threonine-Protein Kinase 6	A	aurora-A kinase, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Surora-related kinase 1, hARK1, Surora-A, Breast-tumor-amplified kinase;
	ec: 2.7.11.1 fragment: RESIDUES 123-401 mutation: T287D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6 expression_system_strain: TUNER (DE3) expression_system_vector_type: PLASMID expression_system_plasmid: pET28a-MBP

Authors :

Martin, M.P., Zhu, J.-Y., Schonbrunn, E.

Keywords :

protein kinase, aurora A, inhibitor, DFG-in, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.7012 Å )

Citation :

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A.

Martin, M.P.,Zhu, J.Y.,Lawrence, H.R. et al.
(2012) Acs Chem.Biol. 7 : 698 - 706

Chain :

UniProt :

O14965 (AURKA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
	-

PDB ID: 3UO5