Brand  (β version)

PDB ID: 3UNK

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Ligands
Code Name Style Show Link
0BY 4-({4-[(2-chlorophenyl)amino]pyrimidin-2-yl}amino)benzoic acid PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3UNK   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CDK2 in complex with inhibitor YL5-083
Release Data : 2012-01-25
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A Cell division protein kinase 2, p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: CDK2
expression_system_strain: TUNER(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pGEX6P-1
Authors : Zhu, J.-Y., Martin, M.P., Alam, R., Schonbrunn, E.
Keywords : Protein kinase, allosteric ligand, ANS, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A.

Martin, M.P.,Zhu, J.Y.,Lawrence, H.R.  et al.
(2012)  Acs Chem.Biol.  7 : 698 - 706

PubMed: 22248356
DOI: 10.1021/cb200508b

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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