Brand  (β version)

PDB ID: 3UNF

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Ligands
Code Name Style Show Link
04C 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol PoSSuM
CL Chloride ion PoSSuM
IOD Iodide ion PoSSuM
K Potassium ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 3UNF   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Mouse 20S immunoproteasome in complex with PR-957
Release Data : 2012-02-29
Compound :
mol_id molecule chains
1 Proteasome subunit alpha type-2 A,O
mol_id molecule chains
2 Proteasome subunit alpha type-4 B,P
mol_id molecule chains
3 Proteasome subunit alpha type-7 C,Q
mol_id molecule chains
4 Proteasome subunit alpha type-5 D,R
mol_id molecule chains
5 Proteasome subunit alpha type-1 E,S
mol_id molecule chains
6 Proteasome subunit alpha type-3 F,T
mol_id molecule chains
7 Proteasome subunit alpha type-6 G,U
mol_id molecule chains
8 Proteasome subunit beta type-10 H,V
mol_id molecule chains
9 Proteasome subunit beta type-3 I,W
mol_id molecule chains
10 Proteasome subunit beta type-2 J,X
mol_id molecule chains
11 Proteasome subunit beta type-8 K,Y
mol_id molecule chains
12 Proteasome subunit beta type-1 L,Z
mol_id molecule chains
13 Proteasome subunit beta type-4 M,a
mol_id molecule chains
14 Proteasome subunit beta type-9 N,b
Source :
mol_id organism_scientific organism_common
1 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
2 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
3 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
4 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
5 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
6 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
7 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
8 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
9 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
10 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
11 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
12 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
13 Mus musculus  (taxid:10090) Mouse
mol_id organism_scientific organism_common
14 Mus musculus  (taxid:10090) Mouse
Authors : Huber, E., Basler, M., Schwab, R., Heinemeyer, W., Kirk, C., Groettrup, M., Groll, M.
Keywords : Proteasome, antigen presentation, drug development, protein degradation, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

Huber, E.M.,Basler, M.,Schwab, R.  et al.
(2012)  Cell(Cambridge,Mass.)  148 : 727 - 738

PubMed: 22341445
DOI: 10.1016/j.cell.2011.12.030

Reaction

Chain : A, O
UniProt : P49722 (PSA2_MOUSE)
Reaction : -
Chain : B, P
UniProt : Q9R1P0 (PSA4_MOUSE)
Reaction : -
Chain : C, Q
UniProt : Q9Z2U0 (PSA7_MOUSE)
Reaction : -
Chain : D, R
UniProt : Q9Z2U1 (PSA5_MOUSE)
Reaction : -
Chain : E, S
UniProt : Q9R1P4 (PSA1_MOUSE)
Reaction : -
Chain : F, T
UniProt : O70435 (PSA3_MOUSE)
Reaction : -
Chain : G, U
UniProt : Q9QUM9 (PSA6_MOUSE)
Reaction : -
Chain : H, V
UniProt : P70195 (PSB7_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 UniProtKB:Q99436
-
Chain : I, W
UniProt : Q9R1P1 (PSB3_MOUSE)
Reaction : -
Chain : J, X
UniProt : Q9R1P3 (PSB2_MOUSE)
Reaction : -
Chain : K, Y
UniProt : O55234 (PSB5_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 UniProtKB:P28074
-
Chain : L, Z
UniProt : O09061 (PSB1_MOUSE)
Reaction : -
Chain : M, a
UniProt : P99026 (PSB4_MOUSE)
Reaction : -
Chain : N, b
UniProt : Q60692 (PSB6_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 UniProtKB:P28072
-