Het-PDB Navi2 (PDB: 3UNB)

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Ligands
Code	Name		Style	Show	Link
04C	1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3UNB

Code :

3UNB PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Mouse constitutive 20S proteasome in complex with PR-957

Release Data :

2012-02-29

Compound :

mol_id	molecule	chains	synonym
1	Proteasome subunit alpha type-2	A,O,c,q	Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
2	Proteasome subunit alpha type-4	B,P,d,r	Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome component C9, Proteasome subunit L
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
3	Proteasome subunit alpha type-7	C,Q,e,s	Proteasome subunit RC6-1
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
4	Proteasome subunit alpha type-5	D,R,f,t	Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
5	Proteasome subunit alpha type-1	E,S,g,u	Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
6	Proteasome subunit alpha type-3	F,T,h,v	Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8, Proteasome subunit K
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
7	Proteasome subunit alpha type-6	G,U,i,w	Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
8	Proteasome subunit beta type-7	H,V,j,x	Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
9	Proteasome subunit beta type-3	I,W,k,y	Proteasome chain 13, Proteasome component C10-II, Proteasome theta chain
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
10	Proteasome subunit beta type-2	J,X,l,z	Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
11	Proteasome subunit beta type-5	K,Y,m,1	Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit X
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
12	Proteasome subunit beta type-1	L,Z,n,2	Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome component C5, Proteasome gamma chain
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
13	Proteasome subunit beta type-4	M,a,o,3	Low molecular mass protein 3, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3
	ec: 3.4.25.1

mol_id	molecule	chains	synonym
14	Proteasome subunit beta type-6	N,b,p,4	Low molecular mass protein 19, Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, Proteasome subunit Y
	ec: 3.4.25.1

Source :

mol_id	organism_scientific	organism_common
1	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
2	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
3	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
4	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
5	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
6	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
7	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
8	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
9	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
10	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
11	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
12	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
13	Mus musculus (taxid:10090)	Mouse

mol_id	organism_scientific	organism_common
14	Mus musculus (taxid:10090)	Mouse

Authors :

Huber, E., Basler, M., Schwab, R., Heinemeyer, W., Kirk, C., Groettrup, M., Groll, M.

Keywords :

20S proteasome comprises 28 subunits; each subunit adopts the fold of an antiparallel beta-sheet flanked by helices, Protease, Regulatory complexes, Covalent binding of PR-957 to all active sites, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.90 Å )

Citation :

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

Huber, E.M.,Basler, M.,Schwab, R. et al.
(2012) Cell(Cambridge,Mass.) 148 : 727 - 738

PubMed: 22341445
DOI: 10.1016/j.cell.2011.12.030

Chain :	A, O, c, q
UniProt :	P49722 (PSA2_MOUSE)
Reaction :	-

Chain :	B, P, d, r
UniProt :	Q9R1P0 (PSA4_MOUSE)
Reaction :	-

Chain :	C, Q, e, s
UniProt :	Q9Z2U0 (PSA7_MOUSE)
Reaction :	-

Chain :	D, R, f, t
UniProt :	Q9Z2U1 (PSA5_MOUSE)
Reaction :	-

Chain :	E, S, g, u
UniProt :	Q9R1P4 (PSA1_MOUSE)
Reaction :	-

Chain :	F, T, h, v
UniProt :	O70435 (PSA3_MOUSE)
Reaction :	-

Chain :	G, U, i, w
UniProt :	Q9QUM9 (PSA6_MOUSE)
Reaction :	-

Chain :

H, V, j, x

UniProt :

P70195 (PSB7_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Cleavage of peptide bonds with very broad specificity.	3.4.25.1	UniProtKB:Q99436
Cleavage of peptide bonds with very broad specificity.	-	UniProtKB:Q99436

Chain :	I, W, k, y
UniProt :	Q9R1P1 (PSB3_MOUSE)
Reaction :	-

Chain :	J, X, l, z
UniProt :	Q9R1P3 (PSB2_MOUSE)
Reaction :	-

Chain :

K, Y, m, 1

UniProt :

O55234 (PSB5_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Cleavage of peptide bonds with very broad specificity.	3.4.25.1	UniProtKB:P28074
Cleavage of peptide bonds with very broad specificity.	-	UniProtKB:P28074

Chain :	L, Z, n, 2
UniProt :	O09061 (PSB1_MOUSE)
Reaction :	-

Chain :	M, a, o, 3
UniProt :	P99026 (PSB4_MOUSE)
Reaction :	-

Chain :

N, b, p, 4

UniProt :

Q60692 (PSB6_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Cleavage of peptide bonds with very broad specificity.	3.4.25.1	UniProtKB:P28072
Cleavage of peptide bonds with very broad specificity.	-	UniProtKB:P28072

PDB ID: 3UNB

Hetero Atom Contents

Structure summary

Reaction