Brand  (β version)

PDB ID: 3UKR

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Ligands
Code Name Style Show Link
CKH 2-fluoro-N-[2-(2-methyl-1h-indol-3-yl)ethyl]benzamide PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 3UKR   PDBj   RCSB PDB   PDBe
Header : STRUCTURAL PROTEIN
Title : Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666
Release Data : 2013-02-13
Compound :
mol_id molecule chains synonym
1 Actin-related protein 3 A Actin-2, Actin-like protein 3
mol_id molecule chains synonym
2 Actin-related protein 2 B Actin-like protein 2
mol_id molecule chains synonym
3 Actin-related protein 2/3 complex subunit 1B C Arp2/3 complex 41 kDa subunit, p41-ARC
mol_id molecule chains synonym
4 Actin-related protein 2/3 complex subunit 2 D Arp2/3 complex 34 kDa subunit, p34-ARC
mol_id molecule chains synonym
5 Actin-related protein 2/3 complex subunit 3 E Arp2/3 complex 21 kDa subunit, p21-ARC
mol_id molecule chains synonym
6 Actin-related protein 2/3 complex subunit 4 F Arp2/3 complex 20 kDa subunit, p20-ARC
mol_id molecule chains synonym
7 Actin-related protein 2/3 complex subunit 5 G Arp2/3 complex 16 kDa subunit, p16-ARC
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
mol_id organism_scientific organism_common
3 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
mol_id organism_scientific organism_common
4 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
mol_id organism_scientific organism_common
5 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
mol_id organism_scientific organism_common
6 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
mol_id organism_scientific organism_common
7 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
Authors : Nolen, B.J., Han, M.
Keywords : BETA-PROPELLER ACTIN FOLD, STRUCTURAL PROTEIN, ATP BINDING
Exp. method : X-RAY DIFFRACTION ( 2.48 Å )
Citation :

Structural characterization and computer-aided optimization of a small-molecule inhibitor of the Arp2/3 complex, a key regulator of the actin cytoskeleton.

Baggett, A.W.,Cournia, Z.,Han, M.S.  et al.
(2012)  Chemmedchem  7 : 1286 - 1294

PubMed: 22623398
DOI: 10.1002/cmdc.201200104

Reaction

Chain : A
UniProt : P61157 (ARP3_BOVIN)
Reaction : -
Chain : B
UniProt : A7MB62 (ARP2_BOVIN)
Reaction : -
Chain : C
UniProt : Q58CQ2 (ARC1B_BOVIN)
Reaction : -
Chain : D
UniProt : Q3MHR7 (ARPC2_BOVIN)
Reaction : -
Chain : E
UniProt : Q3T035 (ARPC3_BOVIN)
Reaction : -
Chain : F
UniProt : Q148J6 (ARPC4_BOVIN)
Reaction : -
Chain : G
UniProt : Q3SYX9 (ARPC5_BOVIN)
Reaction : -