Brand  (β version)

PDB ID: 3UJS

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Ligands
Code Name Style Show Link
0V5 (2r)-2-(phosphonooxy)propanoic acid PoSSuM
MG Magnesium ion PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
XSP (2r)-3-oxo-2-(phosphonooxy)propanoic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 3UJS   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Asymmetric complex of human neuron specific enolase-6-PGA/PEP
Release Data : 2012-08-22
Compound :
mol_id molecule chains synonym
1 Gamma-enolase A,B 2-phospho-D-glycerate hydro-lyase, Enolase 2, Neural enolase, Neuron-specific enolase, NSE
ec: 4.2.1.11
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ENO2
expression_system_vector_type: plasmid
Authors : Qin, J., Chai, G., Brewer, J., Lovelace, L., Lebioda, L.
Keywords : lyase
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.

Qin, J.,Chai, G.,Brewer, J.M.  et al.
(2012)  J.Inorg.Biochem.  111 : 187 - 194

PubMed: 22437160
DOI: 10.1016/j.jinorgbio.2012.02.011

Reaction

Chain : A, B
UniProt : P09104 (ENOG_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate 4.2.1.11 -
-