Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
046 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide
MLI Malonate ion
Code : 3UGC
Header : Transferase/transferase inhibitor
Title : Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594
Release Data : 2012-05-16
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK2 A Janus kinase 2, JAK-2
ec: 2.7.10.2
fragment: unp residues 840-1132
mutation: Y1007F, Y1008F
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
expression_system_cell_line: SF9DE
expression_system_vector_type: PLASMID
expression_system_plasmid: PACG2TTEV
Authors : Scheufler, C., Tavares, G.A., Manley, P.W., Pissot-Soldermann, C., Kroemer, M.
Keywords : Small molecule inhibitor, ATP Binding, Transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.34 Å )
Citation :

Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent.

Andraos, R.,Qian, Z.,Bonenfant, D.  et al.
(2012)  Cancer Discov  2 : 512 - 523

PubMed: 22684457
DOI: 10.1158/2159-8290.CD-11-0324

Chain : A
UniProt : O60674 (JAK2_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.