Het-PDB Navi2 (PDB: 3UGC)

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Ligands
Code	Name		Style	Show	Link
046	5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide				PoSSuM
MLI	Malonate ion				PoSSuM

Non-standard Residues
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Download interaction data: 3UGC

Code :

3UGC PDBj RCSB PDB PDBe

Header :

Transferase/transferase inhibitor

Title :

Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594

Release Data :

2012-05-16

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK2	A	Janus kinase 2, JAK-2
	ec: 2.7.10.2 fragment: unp residues 840-1132 mutation: Y1007F, Y1008F

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	expression_system_cell_line: SF9DE expression_system_vector_type: PLASMID expression_system_plasmid: PACG2TTEV

Authors :

Scheufler, C., Tavares, G.A., Manley, P.W., Pissot-Soldermann, C., Kroemer, M.

Keywords :

Small molecule inhibitor, ATP Binding, Transferase-transferase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.34 Å )

Citation :

Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent.

Andraos, R.,Qian, Z.,Bonenfant, D. et al.
(2012) Cancer Discov 2 : 512 - 523

Chain :

UniProt :

O60674 (JAK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263
	-	PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263

PDB ID: 3UGC