PDB ID: 3UAS
Hetero Atom Contents
color scheme of protein:
|Title :||Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene|
|Release Data :||2013-01-09|
|Authors :||Gay, S.C., Zhang, H., Shah, M.B., Stout, C.D., Halpert, J.R., Hollenberg, P.F.|
|Keywords :||P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4, CYP LM2|
|Exp. method :||X-RAY DIFFRACTION ( 2.9390 Å )|
Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis.
Zhang, H.,Gay, S.C.,Shah, M.
Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
Zhao, Y.,White, M.A.,Muralidhara, B.K.
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.
Scott, E.E.,White, M.A.,He, Y.A.
An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution.
Scott, E.E.,He, Y.A.,Wester, M.R.
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Zhao, Y.,Sun, L.,Muralidhara, B.K.
Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Gay, S.C.,Sun, L.,Maekawa, K.
Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel .
Gay, S.C.,Roberts, A.G.,Maekawa, K.
Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography.
Wilderman, P.R.,Shah, M.B.,Liu, T.
|UniProt :||P00178 (CP2B4_RABIT)|
|Reaction :||RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.|