Brand  (β version)

PDB ID: 3U9Y

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Ligands
Code Name Style Show Link
09L 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2h)-one PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3U9Y   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of human tankyrase 2 catalytic domain in complex with olaparib
Release Data : 2012-01-25
Compound :
mol_id molecule chains synonym
1 Tankyrase-2 A TANK2, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein
ec: 2.4.2.30
fragment: C-terminal fragment, UNP residues 946-1162
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: TNKS2, PARP5B, TANK2, TNKL
expression_system_strain: Rosetta 2(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC-Bsa4
Authors : Narwal, M., Lehtio, L.
Keywords : PROTEIN-LIGAND COMPLEX, DIPHTHERIA TOXIN LIKE FOLD, ADP-RIBOSYLATION, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural basis of selective inhibition of human tankyrases.

Narwal, M.,Venkannagari, H.,Lehtio, L.
(2012)  J.Med.Chem.  55 : 1360 - 1367

PubMed: 22233320
DOI: 10.1021/jm201510p

Reaction

Chain : A
UniProt : Q9H2K2 (TNKS2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:19759537, PubMed:21478859
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L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - ECO:0000305
left-to-right
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - ECO:0000305
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