Brand  (β version)

PDB ID: 3U4W

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
08M N~5~-(pyrazin-2-ylcarbonyl)-L-ornithine
ALC 2-amino-3-cyclohexyl-propionic acid
DAB 2,4-diaminobutyric acid
Glycosylation
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Modification
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FUM Fumaric acid

Structure summary

Code : 3U4W   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Src in complex with DNA-templated macrocyclic inhibitor MC4b
Release Data : 2012-02-22
Compound :
mol_id molecule chains synonym
1 Proto-oncogene tyrosine-protein kinase Src A c-Src kinase, Proto-oncogene c-Src, pp60c-src, p60-Src
ec: 2.7.10.2
fragment: Src kinase domain (UNP residues 259-533)
mol_id molecule chains
2 macrocyclic inhibitor MC4B B
Source :
mol_id organism_scientific organism_common expression_system
1 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:469008)
gene: SRC
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28
mol_id organism_scientific
2
synthetic: yes
Authors : Seeliger, M.A., Liu, D.R., Georghiou, G., Kleiner, R.E., Pulkoski-Gross, M.
Keywords : protein kinase, Src-like inactive conformation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.900 Å )
Citation :

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.

Georghiou, G.,Kleiner, R.E.,Pulkoski-Gross, M.  et al.
(2012)  Nat.Chem.Biol.  8 : 366 - 374

PubMed: 22344177
DOI: 10.1038/nchembio.792

Reaction

Chain : A
UniProt : P00523 (SRC_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028
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