Brand  (β version)

PDB ID: 3U1Y

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
03I (2r)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide PoSSuM
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Structure summary

Code : 3U1Y   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase inhibitor
Title : Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
Release Data : 2012-01-04
Compound :
mol_id molecule chains synonym
1 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase A,B Protein envA, UDP-3-O-acyl-GlcNAc deacetylase
ec: 3.5.1.-
mutation: C40S
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:287) Escherichia coli  (taxid:562)
gene: lpxC, envA, PA4406
Authors : Brown, M., Abramite, J., Liu, S.
Keywords : Pseudomonas aeruginosa, lpxc, gram negative, Hydrolase-Hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Potent inhibitors of LpxC for the treatment of Gram-negative infections.

Brown, M.F.,Reilly, U.,Abramite, J.A.  et al.
(2012)  J.Med.Chem.  55 : 914 - 923

PubMed: 22175825
DOI: 10.1021/jm2014748

Reaction

Chain : A, B
UniProt : P47205 (LPXC_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate 3.5.1.108 HAMAP-Rule:MF_00388, PubMed:9068651
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