Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
03M (5z)-5-[(6-chloro-7-methyl-1h-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione
SO4 Sulfate ion
Code : 3U15
Header : PROTEIN BINDING
Title : Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443
Release Data : 2012-06-27
Compound :
mol_id molecule chains synonym
1 Protein Mdm4 A,B,C,D Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4
fragment: unp residues 14-111
mutation: C17S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: MDM4, MDMX
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Lukacs, C.M., Janson, C.A., Graves, B.J.
Keywords : cell cycle, ubiquitin ligase, MDM2, MDMX, p53, PROTEIN BINDING
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.

Graves, B.,Thompson, T.,Xia, M.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 11788 - 11793

PubMed: 22745160
DOI: 10.1073/pnas.1203789109

Chain : A, B, C, D
UniProt : O15151 (MDM4_HUMAN)
Reaction : -