Brand  (β version)

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Ligands
Code Name Style Show Link
08D Sulfamethoxazole
HH2 6-hydroxymethylpterin-diphosphate
MG Magnesium ion
Non-standard Residues
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Glycosylation
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Code : 3TZF   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/ANTIBIOTIC/INHIBITOR
Title : Crystal Structure of the Yersinia pestis Dihydropteroate Synthase with Sulfonamide Drug Complex.
Release Data : 2012-03-14
Compound :
mol_id molecule chains synonym
1 7,8-dihydropteroate synthase A,B Dihydropteroate synthase
ec: 2.5.1.15
fragment: DHPS
Source :
mol_id organism_scientific expression_system
1 Yersinia pestis  (taxid:632) Escherichia coli  (taxid:469008)
strain: KIM D27
gene: dhpS, folP, y0683, YPO3501, YP_0582
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Wu, Y.
Keywords : Dihydropteroate synthase, sulfonamide complex, Tim barrel, TRANSFERASE-INHIBITOR-ANTIBIOTIC complex, TRANSFERASE-ANTIBIOTIC-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

Catalysis and sulfa drug resistance in dihydropteroate synthase.

Yun, M.K.,Wu, Y.,Li, Z.  et al.
(2012)  Science  335 : 1110 - 1114

PubMed: 22383850
DOI: 10.1126/science.1214641

Chain : A, B
UniProt : Q7CKJ1
Reaction : -