Het-PDB Navi2 (PDB: 3TZ0)

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Ligands
Code	Name		Style	Show	Link
03H	(2s)-2-chloro-4-methylpentanoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3TZ0

Code :

3TZ0 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex

Release Data :

2012-10-03

Compound :

mol_id	molecule	chains	synonym
1	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	A	Branched-chain alpha-ketoacid dehydrogenase kinase, BCKD-kinase, BCKDHKIN
	ec: 2.7.11.4

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Rat	Escherichia coli (taxid:562)
	gene: Bckdk expression_system_strain: BL21GroESL expression_system_vector_type: PLASMID expression_system_plasmid: pTrckHisB

Authors :

Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R.M., Li, J., Chuang, D.T.

Keywords :

GHKL protein kinase, Allosteric kinase inhibitor, Branched-chain alpha-ketoacid, Branched-chain amino acids, Maple syrup urine disease, Diabetes and obesity, Bergerat nucleotide-binding fold, Protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.500 Å )

Citation :

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.

Tso, S.C.,Qi, X.,Gui, W.J. et al.
(2013) Proc.Natl.Acad.Sci.USA 110 : 9728 - 9733

PubMed: 23716694
DOI: 10.1073/pnas.1303220110

PDB ID: 3TZ0

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