Brand  (β version)

PDB ID: 3TVW

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Ligands
Code Name Style Show Link
07H [4-(2h-chromen-3-ylmethyl)piperazin-1-yl]-[3-(1h-pyrazol-5-yl)phenyl]methanone PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3TVW   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 4
Release Data : 2011-10-19
Compound :
mol_id molecule chains synonym
1 Acetyl-CoA carboxylase A,B,C ACC, Fatty acid synthetase 3, mRNA transport-defective protein 7, Biotin carboxylase
ec: 6.4.1.2, 6.3.4.14
fragment: Carboxyltransferase domain, residues 1476-2233
mutation: E1919Q,P1920A,H1925F,P1760S,I1762L,M1765V,Q2028E,M2030T,G2032E
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast Escherichia coli  (taxid:562)
strain: ATCC 204508 / S288c
gene: ACC1, ABP2, FAS3, MTR7, YNR016C, N3175
Authors : Rajamohan, F., Marr, E., Reyes, A., Landro, J.A., Anderson, M.D., Corbett, J.W., Dirico, K.J., Harwood, J.H., Tu, M., Vajdos, F.F.
Keywords : carboxyltransferase, ligase
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.

Rajamohan, F.,Marr, E.,Reyes, A.R.  et al.
(2011)  J.Biol.Chem.  286 : 41510 - 41519

PubMed: 21953464
DOI: 10.1074/jbc.M111.275396

Reaction

Chain : A, B, C
UniProt : Q00955 (ACAC_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+) 6.4.1.2 PubMed:12663926, PubMed:15079078
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N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+) 6.3.4.14 UniProtKB:Q5SWU9
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Cofactor: Evidence: Note:
biotin ECO:0000250 | UniProtKB:O00763
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Mn(2+) ECO:0000250
Binds 2 manganese ions per subunit.