Het-PDB Navi2 (PDB: 3TVQ)

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Ligands
Code	Name		Style	Show	Link
DQH	(2r,3r)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4h-chromen-4-one				PoSSuM

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Download interaction data: 3TVQ

Code :

3TVQ PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of TCM Aro/Cyc complexed with trans-dihidroquercetin

Release Data :

2012-04-04

Compound :

mol_id	molecule	chains
1	Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN	A

Source :

mol_id	organism_scientific	expression_system
1	Streptomyces glaucescens (taxid:1907)	Escherichia coli (taxid:469008)
	gene: tcmN expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PET28A

Authors :

Ames, B.D., Lee, M.-Y., Tsai, S.-C.

Keywords :

TETRACENOMYCIN, AROMATASE, CYCLASE, TAXIFOLIN, DIHYROQUERCETIN, Helix-grip fold, MULTIFUNCTIONAL CYCLASE-DEHYDRATASE-3-O-METHYL TRANSFERASE, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.67 Å )

Citation :

Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI.

Lee, M.Y.,Ames, B.D.,Tsai, S.C.
(2012) Biochemistry 51 : 3079 - 3091

PubMed: 22432862
DOI: 10.1021/bi201705q

Chain :

UniProt :

P16559 (TCMN_STRGA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2	2.3.1.235	PubMed:9609708
	left-to-right	PubMed:9609708

PDB ID: 3TVQ

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Structure summary

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