Brand  (β version)

PDB ID: 3TPX

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
DAL D-alanine
DTR D-tryptophan
DTY D-tyrosine
DSG D-asparagine
TDF 4-(trifluoromethyl)-D-phenylalanine
DGL D-glutamic acid
DLY D-lysine
DLE D-leucine
DAR D-arginine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3TPX   PDBj   RCSB PDB   PDBe
Header : LIGASE/LIGASE INHIBITOR
Title : Crystal structure of human MDM2 in complex with a trifluoromethylated D-peptide inhibitor
Release Data : 2012-06-20
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase Mdm2 A,C,E Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
ec: 6.3.2.-
fragment: p53 binding domain (UNP residues 25-109)
mol_id molecule chains
2 D-peptide inhibitor DPMI-delta B,D,F
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
Authors : Wu, X., Pazgier, M.
Keywords : LIGASE-LIGASE INHIBITOR complex, MDM2-D-peptide inhibitor complex, p53-binding domain of MDM2-D-peptide inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.

Zhan, C.,Zhao, L.,Wei, X.  et al.
(2012)  J.Med.Chem.  55 : 6237 - 6241

PubMed: 22694121
DOI: 10.1021/jm3005465

Reaction

Chain : A, C, E
UniProt : Q00987 (MDM2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:12821780
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