Het-PDB Navi2 (PDB: 3TO6)

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Ligands
Code	Name		Style	Show	Link
CMC	Carboxymethyl coenzyme *a				PoSSuM

Non-standard Residues
Code	Name	Show
ALY	N(6)-acetyllysine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3TO6

Code :

3TO6 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor

Release Data :

2011-11-09

Compound :

mol_id	molecule	chains
1	Histone acetyltransferase ESA1	A
	ec: 2.3.1.48 fragment: UNP residues 160-435

mol_id	molecule	chains	synonym
2	Histone H4	B	K16CoA bisubstrate inhibitor
	fragment: UNP residues 12-23

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Saccharomyces cerevisiae (taxid:4932)	Baker's yeast	Escherichia coli (taxid:562)
	gene: ESA1, YOR244W, O5257

mol_id	organism_scientific	organism_common
2	Saccharomyces cerevisiae (taxid:4932)	Baker's yeast
	synthetic: yes

Authors :

Yuan, H., Ding, E.C., Marmorstein, R.

Keywords :

acetyltransferase, autoacetylation, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.100 Å )

Citation :

MYST protein acetyltransferase activity requires active site lysine autoacetylation.

Yuan, H.,Rossetto, D.,Mellert, H. et al.
(2011) Embo J. 31 : 58 - 70

Chain :

UniProt :

Q08649 (ESA1_YEAST)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)	2.3.1.48	PubMed:12368900, PubMed:17223684, PubMed:18245364, PubMed:22020126, PubMed:9520405
	left-to-right
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)	-	PubMed:22539722, PubMed:29765047
	left-to-right	PubMed:22539722, PubMed:29765047
2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2- hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)	-	UniProtKB:O94446
	left-to-right	UniProtKB:O94446
(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L- lysyl-[protein] + CoA + H(+)	-	PubMed:31699900
	left-to-right	PubMed:31699900

PDB ID: 3TO6