Brand  (β version)

PDB ID: 3TNW

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Ligands
Code Name Style Show Link
F18 4-[(E)-(3,5-diamino-1h-pyrazol-4-yl)diazenyl]phenol PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 3TNW   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Structure of CDK2/cyclin A in complex with CAN508
Release Data : 2012-02-15
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A,C Cell division protein kinase 2, p33 protein kinase
ec: 2.7.11.22
mol_id molecule chains synonym
2 Cyclin-A2 B,D Cyclin-A
fragment: cyclin boxes, UNP resdiues 169-430
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDK2
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:562)
gene: CCNA, CCNA2
Authors : Baumli, S., Hole, A.J., Endicott, J.A.
Keywords : cyclin dependent kinase, kinase cyclin, phosphotransferase, cyclin A, phosphorylation at CDK2 threonine 160, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.

Baumli, S.,Hole, A.J.,Noble, M.E.  et al.
(2012)  Acs Chem.Biol.  7 : 811 - 816

PubMed: 22292676
DOI: 10.1021/cb2004516

Reaction

Chain : A, C
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
Chain : B, D
UniProt : P30274 (CCNA2_BOVIN)
Reaction : -