Brand  (β version)

PDB ID: 3TMZ

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Ligands
Code Name Style Show Link
06X Amlodipine PoSSuM
CM5 5-cyclohexyl-1-pentyl-beta-D-maltoside PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
Non-standard Residues
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Structure summary

Code : 3TMZ   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine
Release Data : 2012-09-12
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 2B4 A CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1
ec: 1.14.14.1
mutation: E2A, G22K, H23K, P24T, K25S, A26S, H27K, R29K, H226Y
Source :
mol_id organism_scientific organism_common expression_system
1 Oryctolagus cuniculus  (taxid:9986) European rabbit,Japanese white rabbit,domestic rabbit,rabbits Escherichia coli  (taxid:562)
gene: CYP2B4
expression_system_strain: TOPP3
expression_system_vector_type: Plasmid
expression_system_plasmid: pKK
Authors : Shah, M.B., Pascual, J., Stout, C.D., Halpert, J.R.
Keywords : P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4
Exp. method : X-RAY DIFFRACTION ( 2.248 Å )
Citation :

Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules.

Shah, M.B.,Wilderman, P.R.,Pascual, J.  et al.
(2012)  Biochemistry  51 : 7225 - 7238

PubMed: 22909231
DOI: 10.1021/bi300894z

Reaction

Chain : A
UniProt : P00178 (CP2B4_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+) 1.14.14.1 -
-
Cofactor: Evidence: Note:
heme - -