Het-PDB Navi2 (PDB: 3TMZ)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
06X	Amlodipine	PoSSuM
CM5	5-cyclohexyl-1-pentyl-beta-D-maltoside	PoSSuM
HEM	Protoporphyrin ix containing Fe	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3TMZ

Code :

3TMZ PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine

Release Data :

2012-09-12

Compound :

mol_id	molecule	chains	synonym
1	Cytochrome P450 2B4	A	CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1
	ec: 1.14.14.1 mutation: E2A, G22K, H23K, P24T, K25S, A26S, H27K, R29K, H226Y

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Oryctolagus cuniculus (taxid:9986)	European rabbit,Japanese white rabbit,domestic rabbit,rabbits	Escherichia coli (taxid:562)
	gene: CYP2B4 expression_system_strain: TOPP3 expression_system_vector_type: Plasmid expression_system_plasmid: pKK

Authors :

Shah, M.B., Pascual, J., Stout, C.D., Halpert, J.R.

Keywords :

P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4

Exp. method :

X-RAY DIFFRACTION ( 2.248 Å )

Citation :

Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules.

Shah, M.B.,Wilderman, P.R.,Pascual, J. et al.
(2012) Biochemistry 51 : 7225 - 7238

Chain :

UniProt :

P00178 (CP2B4_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]	1.14.14.1	-
	-	-

PDB ID: 3TMZ