PDB ID: 3TK3
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Structure summary
Code : | 3TK3 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole | ||||||||||||
Release Data : | 2011-11-16 | ||||||||||||
Compound : |
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Source : |
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Authors : | Gay, S.C., Jang, H.H., Wilderman, P.R., Zhang, Q., Stout, C.D., Halpert, J.R. | ||||||||||||
Keywords : | P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4, CYP LM2 | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.8001 Å ) | ||||||||||||
Citation : |
Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.
Wilderman, P.R.,Gay, S.C.,Jang, H.H.
et al.
PubMed: 22051155 Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
Zhao, Y.,White, M.A.,Muralidhara, B.K.
et al.
PubMed: 16373351 Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.
Scott, E.E.,White, M.A.,He, Y.A.
et al.
PubMed: 15100217 An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution.
Scott, E.E.,He, Y.A.,Wester, M.R.
et al.
PubMed: 14563924 Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Zhao, Y.,Sun, L.,Muralidhara, B.K.
et al.
PubMed: 17887776 Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Gay, S.C.,Sun, L.,Maekawa, K.
et al.
PubMed: 19397311 Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel .
Gay, S.C.,Roberts, A.G.,Maekawa, K.
et al.
PubMed: 20815363 Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography.
Wilderman, P.R.,Shah, M.B.,Liu, T.
et al.
PubMed: 20880847 Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity
C Gay, S.,Zhang, H.,Wilderman, P.R.
et al.
PubMed: 21510666 |
Reaction
Chain : | A, B, C, D | ||||||||
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UniProt : | P00178 (CP2B4_RABIT) | ||||||||
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