Brand  (β version)

PDB ID: 3THS

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Ligands
Code Name Style Show Link
BME Beta-mercaptoethanol PoSSuM
TAM Tris(hydroxyethyl)aminomethane PoSSuM
Non-standard Residues
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Glycosylation
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ACE Acetyl group

Structure summary

Code : 3THS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate pentaglutamate
Release Data : 2011-11-16
Compound :
mol_id molecule chains synonym
1 Glycine N-methyltransferase A,B,C,D Folate-binding protein
ec: 2.1.1.20
mol_id molecule chains
2 5-methyltetrahydrofolate pentaglutamate E,F
Source :
mol_id organism_scientific organism_common
1 Rattus norvegicus  (taxid:10116) Brown rat,rat,rats
mol_id organism_scientific
2
synthetic: yes
Authors : Luka, Z., Pakhomova, S., Loukachevitch, L.V., Newcomer, M.E., Wagner, C.
Keywords : Glycine N-methyltransferase, GNMT, Folate, Folate binding, Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.

Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.  et al.
(2011)  Biochim.Biophys.Acta  1824 : 286 - 291

PubMed: 22037183
DOI: 10.1016/j.bbapap.2011.10.008

Reaction

Chain : A, B, C, D
UniProt : P13255 (GNMT_RAT)
Reaction: EC: Evidence:
Physiological Direction:
glycine + S-adenosyl-L-methionine = sarcosine + S-adenosyl-L- homocysteine + H(+) 2.1.1.20 PubMed:12859184, PubMed:3838667
left-to-right PubMed:12859184