Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
BME Beta-mercaptoethanol
TAM Tris(hydroxyethyl)aminomethane
Modified Residues
Code Name Link
03O 4-({[(6s)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoic acid
ACE Acetyl group
GGL Gamma-L-glutamic acid
Code : 3THS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate pentaglutamate
Release Data : 2011-11-16
Compound :
mol_id molecule chains synonym
1 Glycine N-methyltransferase A,B,C,D Folate-binding protein
ec: 2.1.1.20
mol_id molecule chains
2 5-methyltetrahydrofolate pentaglutamate E,F
Source :
mol_id organism_scientific organism_common
1 Rattus norvegicus  (taxid:10116) Brown rat,rat,rats
mol_id organism_scientific
2
synthetic: yes
Authors : Luka, Z., Pakhomova, S., Loukachevitch, L.V., Newcomer, M.E., Wagner, C.
Keywords : Glycine N-methyltransferase, GNMT, Folate, Folate binding, Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.

Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.  et al.
(2011)  Biochim.Biophys.Acta  1824 : 286 - 291

PubMed: 22037183
DOI: 10.1016/j.bbapap.2011.10.008

Chain : A, B, C, D
UniProt : P13255 (GNMT_RAT)
Reaction : S-adenosyl-L-methionine + glycine = S- adenosyl-L-homocysteine + sarcosine.