Brand  (β version)

PDB ID: 3TH3

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Ligands
Code Name Style Show Link
0GE N-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}-L-alpha-glutamyl-N-[(2s,3s)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]glycinamide PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
CGU Gamma-carboxy-glutamic acid
Glycosylation
Code Name Emphasize
BGC Beta-D-glucopyranose
FUC Alpha-L-fucopyranose
Modification
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Structure summary

Code : 3TH3   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
Release Data : 2012-08-22
Compound :
mol_id molecule chains synonym
1 Coagulation factor VII light chain L Proconvertin, Serum prothrombin conversion accelerator, SPCA
ec: 3.4.21.21
fragment: Coagulation Factor VII
mol_id molecule chains synonym
2 Coagulation factor VII heavy chain H Proconvertin, Serum prothrombin conversion accelerator, SPCA
ec: 3.4.21.21
mol_id molecule chains synonym
3 Tissue factor T TF, Coagulation factor III, Thromboplastin
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
other_details: Blood
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
other_details: Blood
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
other_details: Blood
Authors : Vadivel, K., Agah, S., Cascio, D., Padmanabhan, K., Bajaj, S.P.
Keywords : HYDROLASE, BLOOD CLOTTING, SERINE PROTEASE, BLOOD COAGULATION, Soluble Tissue Factor, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+

Vadivel, K.,Agah, S.,Messer, A.  et al.
To be Published 

Reaction

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-
Chain : T
UniProt : P13726 (TF_HUMAN)
Reaction : -