PDB ID: 3TFQ
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
07M | 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3,4-dihydro-1h-pyrano[3,4-C]pyridine-5-carbonitrile | PoSSuM |
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Download interaction data: 3TFQ
Structure summary
Code : | 3TFQ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Oxidoreductase/Oxidoreductase Inhibitor | ||||||||||||
Title : | Crystal structure of 11b-hsd1 double mutant (l262r, f278e) complexed with 8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE | ||||||||||||
Release Data : | 2011-11-02 | ||||||||||||
Compound : |
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Authors : | Sheriff, S. | ||||||||||||
Keywords : | 11B-HSD1, SDR, DEHYDROGENASE, HYDROXYSTEROID, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.8000 Å ) | ||||||||||||
Citation : |
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1)
Wu, S.C.,Yoon, D.,Chin, J.
et al.
PubMed: 21983444 |
Reaction
Chain : | A, B, D, E | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | P28845 (DHI1_HUMAN) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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