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Ligands
Code Name Style Show Link
FAR Farnesyl
GDP Guanosine-5'-diphosphate
MG Magnesium ion
Non-standard Residues
Code Name Show
CMT O-methylcysteine
Glycosylation
Code Name Emphasize
Modification
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Code : 3T5G   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN,LIPID BINDING PROTEIN
Title : Structure of fully modified farnesylated Rheb in complex with PDE6D
Release Data : 2011-10-26
Compound :
mol_id molecule chains synonym
1 GTP-binding protein Rheb A Ras homolog enriched in brain
mol_id molecule chains synonym
2 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta B GMP-PDE delta, Protein p17
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RHEB, RHEB2
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PDE6D, PDED
Authors : Ismail, S.A., Chen, Y.-X., Wittinghofer, A.
Keywords : Immunoglobulin-like beta sandwitch, PDE delta, Rheb, Farnesyl, SIGNALING PROTEIN, LIPID BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Ismail, S.A.,Chen, Y.X.,Rusinova, A.  et al.
(2011)  Nat.Chem.Biol.  7 : 942 - 949

PubMed: 22002721
DOI: 10.1038/nchembio.686

Chain : A
UniProt : Q15382 (RHEB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - PubMed:15340059, PubMed:22819219
left-to-right
Chain : B
UniProt : O43924 (PDE6D_HUMAN)
Reaction : -