Brand  (β version)

PDB ID: 3T3S

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Ligands
Code Name Style Show Link
HEM Protoporphyrin ix containing Fe PoSSuM
9PL (3s,4r)-3-ethyl-4-[(1-methyl-1h-imidazol-5-yl)methyl]dihydrofuran-2(3h)-one PoSSuM
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Structure summary

Code : 3T3S   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human Cytochrome P450 2A13 in complex with Pilocarpine
Release Data : 2011-12-07
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 2A13 A,B,C,D,E,F,G,H CYPIIA13
ec: 1.14.14.1
fragment: unp residues 31-494
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CYP2A13
expression_system_strain: TOPP3
expression_system_vector_type: plasmid
expression_system_plasmid: pKK2A13dH
Authors : DeVore, N.M., Scott, E.E.
Keywords : CYP2A13, cytochrome P450 2A13, P450 2A13, heme protein, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine.

DeVore, N.M.,Meneely, K.M.,Bart, A.G.  et al.
(2012)  Febs J.  279 : 1621 - 1631

PubMed: 22051186
DOI: 10.1111/j.1742-4658.2011.08412.x

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q16696 (CP2AD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+) 1.14.14.1 -
-
Cofactor: Evidence: Note:
heme - -