Brand  (β version)

PDB ID: 3SW2

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FI1 6-chloro-N-((3s)-2-oxo-1-(2-oxo-2-((5s)-8-oxo-5,6-dihydro-1h-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2h,4h,8h)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide PoSSuM
GOL Glycerol PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3SW2   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide
Release Data : 2011-11-16
Compound :
mol_id molecule chains synonym
1 Coagulation factor X A Stuart factor, Stuart-Prower factor
ec: 3.4.21.6
fragment: Factor X light chain (UNP residues 85-178)
mol_id molecule chains synonym
2 Coagulation factor X B Stuart factor, Stuart-Prower factor
ec: 3.4.21.6
fragment: Activated factor Xa heavy chain (UNP residues 235-472)
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: blood
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: blood
Authors : Klei, H.E.
Keywords : serine protease, epidermal growth factor-like domain, blood coagulation factor, cleavage on pair of basic residues, EGF-like domain, gamma-carboxyglutamic acid, glycoprotein, hydroxylation, zymogen, HYDROLASE, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.420 Å )
Citation :

Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.

Shi, Y.,O'Connor, S.P.,Sitkoff, D.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 7516 - 7521

PubMed: 22041058
DOI: 10.1016/j.bmcl.2011.06.098

Reaction

Chain : B
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
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