Brand  (β version)

PDB ID: 3SR6

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
MTE Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8a,9,10,10a-hexahydro-4h-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester PoSSuM
RMO [arsenothionito(2-)-kappa~2~O,S](oxo)molybdenum PoSSuM
Non-standard Residues
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Structure summary

Code : 3SR6   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Crystal Structure of Reduced Bovine Xanthine Oxidase in Complex with Arsenite
Release Data : 2011-07-27
Compound :
mol_id molecule chains synonym
1 Xanthine dehydrogenase/oxidase A,J Xanthine dehydrogenase, XD, Xanthine oxidase, XO, Xanthine oxidoreductase
ec: 1.17.1.4, 1.17.3.2
fragment: Iron-Sulfur Binding Domain, UNP residues 2-165
mol_id molecule chains synonym
2 Xanthine dehydrogenase/oxidase B,K Xanthine dehydrogenase, XD, Xanthine oxidase, XO, Xanthine oxidoreductase
ec: 1.17.1.4, 1.17.3.2
fragment: Flavin Binding Domain, UNP residues 224-528
mol_id molecule chains synonym
3 Xanthine dehydrogenase/oxidase C,L Xanthine dehydrogenase, XD, Xanthine oxidase, XO, Xanthine oxidoreductase
ec: 1.17.1.4, 1.17.3.2
fragment: Molybdenum Binding Domain, UNP residues 571-1315
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
other_details: Milk
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine
other_details: Milk
mol_id organism_scientific organism_common
3 Bos taurus  (taxid:9913) Bovine
other_details: Milk
Authors : Cao, H., Hille, R.
Keywords : Hydroxylase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

X-ray Crystal Structure of Arsenite-Inhibited Xanthine Oxidase: Mu-Sulfido,Mu-Oxo Double Bridge between Molybdenum and Arsenic in the Active Site.

Cao, H.,Hall, J.,Hille, R.
(2011)  J.Am.Chem.Soc.  133 : 12414 - 12417

PubMed: 21761899
DOI: 10.1021/ja2050265

Reaction

Chain : C, L
UniProt : P80457 (XDH_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
xanthine + NAD(+) + H2O = urate + NADH + H(+) 1.17.1.4 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
-
hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+) 1.17.1.4 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
-
xanthine + O2 + H2O = urate + H2O2 1.17.3.2 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
-
Cofactor: Evidence: Note:
[2Fe-2S] cluster ECO:0000269 | PubMed:12421831
ECO:0000269 | PubMed:15148401
ECO:0000269 | PubMed:19109252
Binds 2 [2Fe-2S] clusters per subunit.
FAD ECO:0000269 | PubMed:12421831
ECO:0000269 | PubMed:15148401
ECO:0000269 | PubMed:19109252
Binds 2 [2Fe-2S] clusters per subunit.
Mo-molybdopterin ECO:0000269 | PubMed:12421831
ECO:0000269 | PubMed:15148401
ECO:0000269 | PubMed:19109252
Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.