PDB ID: 3SL8
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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EDO | 1,2-ethanediol | PoSSuM | |||
ZN | Zinc ion | PoSSuM | |||
PEG | Di(hydroxyethyl)ether | PoSSuM | |||
JN7 | 3-cyclopentyl 6-ethenyl 2-[(thiophen-2-ylacetyl)amino]-4,7-dihydrothieno[2,3-C]pyridine-3,6(5h)-dicarboxylate | PoSSuM |
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Download interaction data: 3SL8
Structure summary
Code : | 3SL8 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Hydrolase/Hydrolase Inhibitor | ||||||||||||
Title : | Crystal structure of the catalytic domain of PDE4D2 with compound 10o | ||||||||||||
Release Data : | 2011-10-26 | ||||||||||||
Compound : |
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Authors : | Feil, S.F. | ||||||||||||
Keywords : | catalytic mechanism, cAMP hydrolysis, Hydrolase-Hydrolase Inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.6000 Å ) | ||||||||||||
Citation : |
Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2.
Nankervis, J.L.,Feil, S.C.,Hancock, N.C.
et al.
PubMed: 22030030 |
Reaction
Chain : | A, B, C, D | ||||||||
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UniProt : | Q08499 (PDE4D_HUMAN) | ||||||||
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