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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol
ZN Zinc ion
PEG Di(hydroxyethyl)ether
JN7 3-cyclopentyl 6-ethenyl 2-[(thiophen-2-ylacetyl)amino]-4,7-dihydrothieno[2,3-C]pyridine-3,6(5h)-dicarboxylate
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Code : 3SL8   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : Crystal structure of the catalytic domain of PDE4D2 with compound 10o
Release Data : 2011-10-26
Compound :
mol_id molecule chains synonym
1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D A,B,C,D DPDE3, PDE43
ec: 3.1.4.17
fragment: Catalytic domain, UNP residues 381-741
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PDE4D, DPDE3
expression_system_strain: BL21(DE3) Star Rosetta
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b
Authors : Feil, S.F.
Keywords : catalytic mechanism, cAMP hydrolysis, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.6000 Å )
Citation :

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2.

Nankervis, J.L.,Feil, S.C.,Hancock, N.C.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 7089 - 7093

PubMed: 22030030
DOI: 10.1016/j.bmcl.2011.09.109

Chain : A, B, C, D
UniProt : Q08499 (PDE4D_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
3',5'-cyclic AMP + H2O = AMP + H(+) 3.1.4.53 PubMed:9371713
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