Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FB6 6-(dihydroxyboranyl)-2-methyl-L-norleucine
MN Manganese (II) ion
Code : 3SL1
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of P. falciparum arginase complexed with 2-amino-6-borono-2-methylhexanoic acid
Release Data : 2011-07-20
Compound :
mol_id molecule chains
1 Arginase A
ec: 3.5.3.1
fragment: UNP residues 22-411
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:36329) Escherichia coli  (taxid:469008)
strain: 3D7
gene: pfi0320w
expression_system_strain: Bl21 Codonplustm(de3) Ril
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a
Authors : Dowling, D.P., Ilies, M., Christianson, D.W.
Keywords : metallohydrolase, arginase fold, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.902 Å )
Citation :

Binding of alpha,alpha-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design

Ilies, M.,Di Costanzo, L.,Dowling, D.P.  et al.
(2011)  J.Med.Chem. 

PubMed: 21728378
DOI: 10.1021/jm200443b

Chain : A
UniProt : Q8I384 (No found in current UniProtKB/SwissProt)
Reaction : -