Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
054 1-[(2-aminopyridin-4-yl)methyl]-3-(2,4-dioxo-1,2-dihydrothieno[3,4-D]pyrimidin-3(4h)-yl)-5-(trifluoromethyl)-1h-indole-2-carboxylic acid
PO4 Phosphate ion
Code : 3SKE
Header : transferase/transferase INHIBITOR
Title : I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles
Release Data : 2011-08-31
Compound :
mol_id molecule chains synonym
1 HCV NS5B RNA_DEPENDENT RNA POLYMERASE A,B RNA-directed RNA polymerase
ec: 2.7.7.48
fragment: unp residues 2420-2989
Source :
mol_id organism_scientific organism_common expression_system
1 Hepatitis C virus isolate HC-J4  (taxid:420174) HCV Escherichia coli  (taxid:562)
strain: HC-J4
Authors : Lesburg, C.A., Anilkumar, G.N.
Keywords : RNA-dependent RNA polymerase, transferase-transferase INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.97 Å )
Citation :

I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.

Anilkumar, G.N.,Lesburg, C.A.,Selyutin, O.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 5336 - 5341

PubMed: 21840715
DOI: 10.1016/j.bmcl.2011.07.021

Chain : A, B
UniProt : O92972 (POLG_HCVJ4)
Reaction : Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
NTP + H(2)O = NDP + phosphate.
ATP + H(2)O = ADP + phosphate.